Induction of photosensitivity by heterologous expression of melanopsin

@article{Qiu2005InductionOP,
  title={Induction of photosensitivity by heterologous expression of melanopsin},
  author={X. Qiu and T. Kumbalasiri and S. M. Carlson and Kwoon Y. Wong and V. Krishna and I. Provencio and D. Berson},
  journal={Nature},
  year={2005},
  volume={433},
  pages={745-749}
}
Melanopsin has been proposed to be the photopigment of the intrinsically photosensitive retinal ganglion cells (ipRGCs); these photoreceptors of the mammalian eye drive circadian and pupillary adjustments through direct projections to the brain. Their action spectrum (λ max ≈ 480 nm) implicates an opsin and melanopsin is the only opsin known to exist in these cells. Melanopsin is required for ipRGC photosensitivity and for behavioural photoresponses that survive disrupted rod and cone function… Expand
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  • 2005
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