Induction of photoreceptor-specific phenotypes in adult mammalian iris tissue

  title={Induction of photoreceptor-specific phenotypes in adult mammalian iris tissue},
  author={Masatoshi Haruta and Mitsuko Kosaka and Yumi Kanegae and Izumu Saito and Tomoyuki Inoue and Ryoichiro Kageyama and Akihiro Nishida and Yoshihito Honda and Masayo Takahashi},
  journal={Nature Neuroscience},
We show that iris tissue in the adult rat eye, which is embryonically related to the neural retina, can generate cells expressing differentiated neuronal antigens. In addition, the Crx gene transfer induced the specific antigens for rod photoreceptors in the iris-derived cells, which was not seen in the adult hippocampus-derived neural stem cells. Our findings demonstrate a remarkable plasticity of adult iris tissue with potential clinical applications, as autologous iris tissue can be feasibly… CONTINUE READING


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Induction of rod photoreceptor-specific antigens with Crx gene transfer. (a, b, d) Iris-derived cells infected with Crx-transducing adenovirus expressed rhodopsin

T. Watanabe, M. C. Raff
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