Induction of phospholipase A2 gene expression in human hepatoma cells by mediators of the acute phase response.

Abstract

Serum levels of phospholipase A2 (PLA2) activity have been shown to be elevated in cases of septic shock and rheumatoid arthritis. The cellular origin of serum PLA2, however, is not known. In this report, we demonstrate that human group II PLA2 expression and secretion are induced in hepatoma cells (HepG2) following treatment with interleukin-6 (IL-6… (More)

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@article{Crowl1991InductionOP, title={Induction of phospholipase A2 gene expression in human hepatoma cells by mediators of the acute phase response.}, author={Robert M Crowl and Timothy J. Stoller and Rushika Conroy and Charlotte R Stoner}, journal={The Journal of biological chemistry}, year={1991}, volume={266 4}, pages={2647-51} }