Induction of phase 2 genes by sulforaphane protects retinal pigment epithelial cells against photooxidative damage.

@article{Gao2004InductionOP,
  title={Induction of phase 2 genes by sulforaphane protects retinal pigment epithelial cells against photooxidative damage.},
  author={Xiangqun Gao and Paul Talalay},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 28},
  pages={10446-51}
}
The retinal pigment epithelial cell (RPE cell) layer protects the photoreceptors of the retina against oxidative stress. The decline of this capacity is believed to be a major factor in the impairment of vision in age-related macular degeneration. Exposure of human adult RPE cells to UV light at predominantly 320-400 nm (UVA light) in the presence of all-trans-retinaldehyde results in photooxidative cytotoxicity. Significant protection of RPE cells was obtained by prior treatment with phase 2… CONTINUE READING

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