Induction of petite mutation with acriflavine and elevated temperature in Candida albicans.

@article{Aoki1987InductionOP,
  title={Induction of petite mutation with acriflavine and elevated temperature in Candida albicans.},
  author={Shigeji Aoki and Shoko Ito-Kuwa},
  journal={Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology},
  year={1987},
  volume={25 4},
  pages={269-77}
}
A method of inducing respiratory deficient (petite) mutation in Candida albicans (which has been previously classed as a petite-negative yeast) and characteristics of some isolated mutants are reported. When grown at 42 degrees C in the presence of a cytoplasmic mutagen (acriflavine), C. albicans exhibited diauxie-like biphasic growth. Mutants which were unable to grow on a non-fermentable substrate, glycerol, were isolated from the above culture at a frequency of less than 1%. The simultaneous… CONTINUE READING

From This Paper

Topics from this paper.