Induction of persistent colitis by a human commensal, enterotoxigenic Bacteroides fragilis, in wild-type C57BL/6 mice.

@article{Rhee2009InductionOP,
  title={Induction of persistent colitis by a human commensal, enterotoxigenic Bacteroides fragilis, in wild-type C57BL/6 mice.},
  author={Ki-Jong Rhee and Shaoguang Wu and Xinqun Wu and David Leonard Huso and Baktiar O. Karim and Augusto A Franco and Shervin Rabizadeh and Jonathan Eric Golub and Lauren E Mathews and Jai Moo Shin and Ryan Balfour Sartor and Douglas T Golenbock and Abdel Rahmin A Hamad and C. Y. Michael Gan and Franck Housseau and Cynthia L Sears},
  journal={Infection and immunity},
  year={2009},
  volume={77 4},
  pages={1708-18}
}
Enterotoxigenic Bacteroides fragilis (ETBF) causes diarrhea and is implicated in inflammatory bowel diseases and colorectal cancer. The only known ETBF virulence factor is the Bacteroides fragilis toxin (BFT), which induces E-cadherin cleavage, interleukin-8 secretion, and epithelial cell proliferation. A murine model for ETBF has not been characterized. Specific pathogen-free (SPF) C57BL/6J or germfree 129S6/SvEv mice were orally inoculated with wild-type ETBF (WT-ETBF) strains, a nontoxigenic… CONTINUE READING