Induction of peripheral tolerance by intrathymic inoculation of soluble alloantigens: evidence for the role of host antigen-presenting cells and suppressor cell mechanism.

@article{Oluwole1995InductionOP,
  title={Induction of peripheral tolerance by intrathymic inoculation of soluble alloantigens: evidence for the role of host antigen-presenting cells and suppressor cell mechanism.},
  author={Soji F D Oluwole and Ming Jin and Nepal Chowdhury and Kristin E Engelstad and O A Ohajekwe and Tharappel James},
  journal={Cellular immunology},
  year={1995},
  volume={162 1},
  pages={
          33-41
        }
}
Intrathymic (IT) inoculation of soluble alloantigens (Ag) obtained from 3 M KCl extracts of resting T-cells induces donor-specific tolerance to cardiac allografts and islet allografts. This study examined the cellular basis of induction of transplantation tolerance by IT injection of soluble Ag. Our results show that while IT inoculation of 2 mg soluble donor Ag on Day -7 relative to Lewis islet transplantation induced specific unresponsiveness to islet allografts (> 200 days) in naive diabetic… CONTINUE READING

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