Induction of peptidylarginine deiminase 2 and 3 by dibutyryl cAMP via cAMP-PKA signaling in human astrocytoma U-251MG cells.

@article{Masutomi2017InductionOP,
  title={Induction of peptidylarginine deiminase 2 and 3 by dibutyryl cAMP via cAMP-PKA signaling in human astrocytoma U-251MG cells.},
  author={Hirofumi Masutomi and Saki Kawashima and Yoshitaka Kondo and Yoshiaki Uchida and Byungki Jang and Eun-Kyoung Choi and Yong-Sun Kim and Kentaro Shimokado and Akihito Ishigami},
  journal={Journal of neuroscience research},
  year={2017},
  volume={95 7},
  pages={
          1503-1512
        }
}
Peptidylarginine deiminases (PADs) are posttranslational modification enzymes that citrullinate (deiminate) protein arginine residues in a calcium-dependent manner, yielding citrulline residues. Enzymatic citrullination abolishes positive charges of native protein molecules, inevitably causing significant alterations in their structure and function… CONTINUE READING