Induction of pathogenic sets of genes in macrophages and neurons in NeuroAIDS.

@article{Roberts2003InductionOP,
  title={Induction of pathogenic sets of genes in macrophages and neurons in NeuroAIDS.},
  author={Eleanor S Roberts and Michelle A Zandonatti and Debbie D Watry and Lisa J. Madden and Steven J. Henriksen and Michael A Taffe and Howard S. Fox},
  journal={The American journal of pathology},
  year={2003},
  volume={162 6},
  pages={2041-57}
}
The etiology of the central nervous system (CNS) alterations after human immunodeficiency virus (HIV) infection, such as dementia and encephalitis, remains unknown. We have used microarray analysis in a monkey model of neuroAIDS to identify 98 genes, many previously unrecognized in lentiviral CNS pathogenesis, whose expression is significantly up-regulated in the frontal lobe of simian immunodeficiency virus-infected brains. Further, through immunohistochemical illumination, distinct classes of… CONTINUE READING