Induction of papillomas with a high probability of conversion to malignancy.

@article{Hennings1985InductionOP,
  title={Induction of papillomas with a high probability of conversion to malignancy.},
  author={Henry Hennings and Robert Shores and Paul Mitchell and Edwin F. Spangler and Stuart H. Yuspa},
  journal={Carcinogenesis},
  year={1985},
  volume={6 11},
  pages={1607-10}
}
Papillomas induced by standard initiation-promotion protocols progress to carcinomas at a low frequency. Experimental protocols were developed to elicit papillomas with a higher probability of malignant conversion. SENCAR mice initiated by 7,12-dimethylbenz[a]anthracene were promoted by treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) for 5, 10, 20 or 40 weeks. With promotion for 10 weeks or more, a peak of papilloma incidence at 16-20 weeks was followed by a 35-40% decrease within 3… CONTINUE READING