Induction of pancreatic differentiation by signals from blood vessels.

@article{Lammert2001InductionOP,
  title={Induction of pancreatic differentiation by signals from blood vessels.},
  author={Eckhard Lammert and Ondine Cleaver and Douglas Melton},
  journal={Science},
  year={2001},
  volume={294 5542},
  pages={564-7}
}
Blood vessels supply developing organs with metabolic sustenance. Here, we demonstrate a role for blood vessels as a source of developmental signals during pancreatic organogenesis. In vitro experiments with embryonic mouse tissues demonstrate that blood vessel endothelium induces insulin expression in isolated endoderm. Removal of the dorsal aorta in Xenopus laevis embryos results in the failure of insulin expression in vivo. Furthermore, using transgenic mice, we show that ectopic… CONTINUE READING
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