Induction of pCW3-encoded tetracycline resistance in Clostridium perfringens involves a host-encoded factor.

@article{Johanesen2001InductionOP,
  title={Induction of pCW3-encoded tetracycline resistance in Clostridium perfringens involves a host-encoded factor.},
  author={Priscilla A. Johanesen and Dena Lyras and Julian I. Rood},
  journal={Plasmid},
  year={2001},
  volume={46 3},
  pages={
          229-32
        }
}
The tetracycline resistance determinant Tet P, which is encoded by the conjugative plasmid pCW3 from Clostridium perfringens, is induced by subinhibitory concentrations of tetracycline. In this study we have shown that the inducible phenotype is strain dependent. When pCW3 is present in derivatives of the wild-type strains CW234 and CW362 resistance is inducible. However, transfer to derivatives of strain 13 leads to a constitutive phenotype that is only observed in this strain background… Expand
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The complete nucleotide sequence and mechanism of action of the tetracycline‐resistance determinant Tet P, from Clostridium perfringens has been determined and it is proposed that tetB(P) evolved from the conjugative transfer into C. perfrings of a fer (M)‐like gene from another bacterium. Expand
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