Induction of p53 Expression and Function by Estrogen in Osteoblasts

  title={Induction of p53 Expression and Function by Estrogen in Osteoblasts},
  author={S. Bovenkerk and N J Lanciloti and Nalini Chandar},
  journal={Calcified Tissue International},
While estrogen’s role in maintaining bone health relates to its action on osteoclasts, not much is presently known about the role of estrogen with respect to osteoblasts. Our laboratory is involved in studying the function of the p53 tumor suppressor gene in osteoblast differentiation. This study was therefore designed to understand the role of estrogen in osteoblast growth and differentiation and its effect on p53 function. ROS 17/2.8 cells, stably transfected with a construct containing… CONTINUE READING