Induction of oxidative stress by glutathione depletion causes severe hypertension in normal rats.

@article{Vaziri2000InductionOO,
  title={Induction of oxidative stress by glutathione depletion causes severe hypertension in normal rats.},
  author={Nosratola D. Vaziri and Xiao Qi Wang and Fariba Oveisi and Behnam Masoud Rad},
  journal={Hypertension},
  year={2000},
  volume={36 1},
  pages={142-6}
}
Several recent studies have shown that certain forms of genetic or acquired hypertension are associated with oxidative stress and that animals with those types of hypertension respond favorably to antioxidant therapy. We hypothesize that oxidative stress may cause hypertension via (among other mechanisms) enhanced oxidation and inactivation of nitric oxide (NO). To test this hypothesis, Sprague-Dawley rats were subjected to oxidative stress by glutathione (GSH) depletion by means of the GSH… CONTINUE READING

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