Induction of oxidative DNA damage by ferric iron in mammalian cells.

@article{Hartwig1995InductionOO,
  title={Induction of oxidative DNA damage by ferric iron in mammalian cells.},
  author={Andrea Hartwig and Regina Schlepegrell},
  journal={Carcinogenesis},
  year={1995},
  volume={16 12},
  pages={3009-13}
}
Ferric nitrilotriacetate (Fe-NTA) and ferric citrate (Fe-citrate) were compared with respect to their potential to induce oxidative DNA damage in V79 Chinese hamster cells. DNA base modifications, including 8-hydroxyguanine (7,8-dihydro-8-oxoguanine), were quantified by the frequency of lesions recognized by the bacterial Fpg protein (formamidopyrimidine… CONTINUE READING