Induction of oxidative DNA damage by carcinogenic metals.

  title={Induction of oxidative DNA damage by carcinogenic metals.},
  author={Wojciech Bal and Kazimierz S. Kasprzak},
  journal={Toxicology letters},
  volume={127 1-3},
The metal ions carcinogenic to humans are As, Be, Cd, Cr and Ni, and the candidates also include Co, Cu, Fe and Pt. A range of molecular mechanisms was proposed for these metals, reflecting their diverse chemical properties. The oxidative concept in metal carcinogenesis proposes that some complexes of the above metals (Co, Cr, Cu, Fe, Ni) formed in vivo undergo redox cycling, yielding reactive oxygen species and/or high valence metal ions which oxidize DNA. Some of the products of oxidative DNA… CONTINUE READING


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