Induction of ovulation and fertility in amenorrheic women by pulsatile low-dose gonadotropin-releasing hormone.

@article{Hurley1984InductionOO,
  title={Induction of ovulation and fertility in amenorrheic women by pulsatile low-dose gonadotropin-releasing hormone.},
  author={Dana M. Hurley and R J Brian and K H Outch and J Stockdale and Alison Fry and C H Hackman and Iain Clarke and H. G. Burger},
  journal={The New England journal of medicine},
  year={1984},
  volume={310 17},
  pages={1069-74}
}
In functional hypothalamic amenorrhea, failure of ovulation probably results from deficient hypothalamic secretion of gonadotropin-releasing hormone (GnRH). We treated 14 infertile women in whom this condition was resistant to clomiphene with pulses of 5 to 15 micrograms of GnRH administered subcutaneously by portable pumps at 90-minute intervals in 36 cycles of treatment. Ovulation occurred in 30 cycles (83 per cent) and was followed by normal luteal function in 24. Singleton pregnancy… CONTINUE READING