Induction of osteoclasts from CD14-positive human peripheral blood mononuclear cells by receptor activator of nuclear factor kappaB ligand (RANKL).

@article{Nicholson2000InductionOO,
  title={Induction of osteoclasts from CD14-positive human peripheral blood mononuclear cells by receptor activator of nuclear factor kappaB ligand (RANKL).},
  author={Geoffrey Charles Nicholson and Mary Malakellis and Fiona McL Collier and Paul U Cameron and Wayne R Holloway and Tamara J. Gough and Claudia C Gregorio-King and Mark Alexander Kirkland and Damian E. Myers},
  journal={Clinical science},
  year={2000},
  volume={99 2},
  pages={133-40}
}
Osteoclasts are bone-resorbing cells that are derived from haemopoietic precursors, including cells present in peripheral blood. The recent identification of RANKL [receptor activator of nuclear factor (NF)-kappaB ligand], a new member of the tumour necrosis factor ligand superfamily that has a key role in osteoclastogenesis, has allowed the in vitro generation of osteoclasts in the absence of cells of the stromal/osteoblast lineage. Human peripheral blood mononuclear cells (PBMC) cultured in… CONTINUE READING