Induction of osteoclast differentiation by Runx2 through receptor activator of nuclear factor-kappa B ligand (RANKL) and osteoprotegerin regulation and partial rescue of osteoclastogenesis in Runx2-/- mice by RANKL transgene.

@article{Enomoto2003InductionOO,
  title={Induction of osteoclast differentiation by Runx2 through receptor activator of nuclear factor-kappa B ligand (RANKL) and osteoprotegerin regulation and partial rescue of osteoclastogenesis in Runx2-/- mice by RANKL transgene.},
  author={Hirayuki Enomoto and Satoko Shiojiri and Kazuto Hoshi and Tatsuya Furuichi and Ryo Fukuyama and Carolina Andrea Yoshida and Naoko Kanatani and Reiko Nakamura and Atsuko Mizuno and Akira Zanma and Kazuki Yano and Hisataka Yasuda and Kanji Higashio and Kenji Takada and Toshihisa Komori},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 26},
  pages={23971-7}
}
Receptor activator of nuclear factor-kappaB ligand (RANKL), osteoprotegerin (OPG), and macrophage-colony stimulating factor play essential roles in the regulation of osteoclastogenesis. Runx2-deficient (Runx2-/-) mice showed a complete lack of bone formation because of maturational arrest of osteoblasts and disturbed chondrocyte maturation. Further, osteoclasts were absent in these mice, in which OPG and macrophage-colony stimulating factor were normally expressed, but RANKL expression was… CONTINUE READING
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