Induction of ornithine decarboxylase in T/C-28a2 chondrocytes by lysophosphatidic acid: signaling pathway and inhibition of cell proliferation.

@article{Facchini2005InductionOO,
  title={Induction of ornithine decarboxylase in T/C-28a2 chondrocytes by lysophosphatidic acid: signaling pathway and inhibition of cell proliferation.},
  author={Annalisa Facchini and Rosa Maria Borz{\`i} and Flavio Flamigni},
  journal={FEBS letters},
  year={2005},
  volume={579 13},
  pages={2919-25}
}
Among several extracellular messengers tested, lysophosphatidic acid (LPA) was able to cause the most marked induction of ornithine decarboxylase (ODC) in serum-starved human T/C-28a2 chondrocytes. LPA also induced the activation/phosphorylation of Src, Akt and p44/42 MAPK, and the translocation of PKC-delta from cytosol to membrane coupled to its tyrosine… CONTINUE READING