Induction of oncogene addiction shift to NF-kappaB by camptothecin in solid tumor cells.

@article{Togano2009InductionOO,
  title={Induction of oncogene addiction shift to NF-kappaB by camptothecin in solid tumor cells.},
  author={Tomiteru Togano and Masataka Sasaki and Mariko Watanabe and Makoto Nakashima and Takashi Tsuruo and Kazuo Umezawa and Masaaki Higashihara and Toshiki Watanabe and Ryouichi Horie},
  journal={Biochemical and biophysical research communications},
  year={2009},
  volume={390 1},
  pages={60-4}
}
The biological basis of the resistance of solid tumor cells to chemotherapy is not well understood. While addressing this problem, we found that gastric cancer cell line St-4/CPT, lung cancer cell line A549/CPT, and colon cancer cell line HT-29/CPT, all of which are resistant to camptothecin (CPT), showed strong and constitutive nuclear factor (NF)-kappaB activity driven by IkappaB kinase compared with their parental cell lines St-4, A549, and HT-29. A new NF-kappaB inhibitor… CONTINUE READING