Induction of nuclear factor-kappa B during primary B cell differentiation.

  title={Induction of nuclear factor-kappa B during primary B cell differentiation.},
  author={Barbara Kistler and Antonius G. Rolink and Ralf B. Marienfeld and Manfred Neumann and Thomas Wirth},
  journal={Journal of immunology},
  volume={160 5},
We have investigated activation of nuclear factor-kappa B (NF-kappa B) in the process of primary B cell differentiation in vitro. In this system, NF-kappa B is strongly induced when B cells develop from the pre-B cell to the immature B cell stage. Unlike the typical NF-kappa B activation in response to exogenous stimuli, induction proceeds with a slow time course. NF-kappa B induction is only observed in B cells that undergo differentiation, not in Rag2-deficient cells. Nuclear DNA binding… CONTINUE READING