Induction of nitric oxide synthase is involved in the mechanism of Fas-mediated apoptosis in haemopoietic cells.

@article{Selleri1997InductionON,
  title={Induction of nitric oxide synthase is involved in the mechanism of Fas-mediated apoptosis in haemopoietic cells.},
  author={Carmine Selleri and Tsutomu Sato and Anna Maria Raiola and Bruno Rotoli and Neal S. Young and J P Maciejewski},
  journal={British journal of haematology},
  year={1997},
  volume={99 3},
  pages={481-9}
}
Induction of nitric oxide synthase (iNOS) and production of the toxic metabolite nitric oxide (NO) is one of the interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha) regulated effector mechanisms that can lead to apoptosis of haemopoietic progenitor cells. Fas-receptor (Fas-R) expression can be stimulated by IFN-gamma and TNF-alpha. Transactivation of iNOS, and possibly Fas-R promoters, by interferon regulatory factor-1 expressed in response to IFN-gamma may be a part of… CONTINUE READING
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