Induction of nitric oxide production by the peritoneal macrophages after intraperitoneal or subcutaneous transplantation of AK-5 tumor.


We have investigated the role of host macrophages in the activation of effector functions in addition to their direct role in the induction of tumor cell death. Peritoneal macrophages from s.c. tumor-bearing animals were in an activated state and induced NO-mediated apoptotic death in AK-5 tumor cells. They also showed overexpression of inducible nitric… (More)


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