Induction of neutrophil extracellular DNA lattices by placental microparticles and IL-8 and their presence in preeclampsia.

@article{Gupta2005InductionON,
  title={Induction of neutrophil extracellular DNA lattices by placental microparticles and IL-8 and their presence in preeclampsia.},
  author={Anurag Kumar Gupta and Paul Hasler and Wolfgang Holzgreve and Stefan Gebhardt and Sinuhe Hahn},
  journal={Human immunology},
  year={2005},
  volume={66 11},
  pages={1146-54}
}
Preeclampsia, a severe pregnancy-related disorder, involves an overt activation of the maternal innate immune system, proposed to result from the elevated release of inflammatory syncytiotrophoblast microparticles (STBM) and cytokines from underlying placental anomaly involving abnormal trophoblast differentiation. Activation of circulating neutrophils has recently been shown to lead to the generation of fibrous extracellular lattices containing DNA, termed NETs (neutrophil extracellular traps… CONTINUE READING