Induction of neutrophil chemotaxis by the quorum-sensing molecule N-(3-oxododecanoyl)-L-homoserine lactone.

@article{Zimmermann2006InductionON,
  title={Induction of neutrophil chemotaxis by the quorum-sensing molecule N-(3-oxododecanoyl)-L-homoserine lactone.},
  author={Sabine C Zimmermann and Christof Wagner and Wencke M{\"u}ller and Gerald Brenner-Wei\ss and F. Hug and Birgit Prior and Ursula Obst and Gertrud Maria Haensch},
  journal={Infection and immunity},
  year={2006},
  volume={74 10},
  pages={5687-92}
}
Acyl homoserine lactones are synthesized by Pseudomonas aeruginosa as signaling molecules which control production of virulence factors and biofilm formation in a paracrine manner. We found that N-(3-oxododecanoyl)-L-homoserine lactone (3OC12-HSL), but not its 3-deoxo isomer or acyl-homoserine lactones with shorter fatty acids, induced the directed migration (chemotaxis) of human polymorphonuclear neutrophils (PMN) in vitro. By use of selective inhibitors a signaling pathway, comprising… CONTINUE READING

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