Induction of neutralizing antibodies in mice immunized with scorpion toxins detoxified by liposomal entrapment.

Abstract

The possibility of producing neutralizing antibodies against the lethal effects of scorpion toxins was evaluated in the mouse model by immunization with an immunogen devoid of toxicity. A toxic fraction (5 mg) from the venom of the scorpion Tityus serrulatus was entrapped in sphingomyelin-cholesterol liposomes. The liposomes were treated for 1 h at 37… (More)

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@article{Fonseca1997InductionON, title={Induction of neutralizing antibodies in mice immunized with scorpion toxins detoxified by liposomal entrapment.}, author={Simone Gonçalves Fonseca and A V M Ferreira and Carlos A. R. Diniz and C. Ch{\'a}vez-Ol{\'o}rtegui}, journal={Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas}, year={1997}, volume={30 7}, pages={883-6} }