Induction of neuronal differentiation of adult human olfactory neuroepithelial-derived progenitors.

@article{Zhang2006InductionON,
  title={Induction of neuronal differentiation of adult human olfactory neuroepithelial-derived progenitors.},
  author={Xiaodong Zhang and Kathleen M. Klueber and Zhanfang Guo and Jun Cai and Chengliang Lu and Welby I Winstead and Mengsheng Qiu and Fred J. Roisen},
  journal={Brain research},
  year={2006},
  volume={1073-1074},
  pages={109-19}
}
Neurosphere forming cells (NSFCs) have been established from cultures of adult olfactory neuroepithelium obtained from patients and cadavers as described previously. They remained undifferentiated in serum or defined media with or without neurotrophic factors. Many factors affect the differentiation of stem cells along a neuronal pathway. Retinoic acid (RA), forskolin (FN), and sonic hedgehog (Shh) have been reported to act as growth promoters during neurogenesis of embryonic CNS in vivo. The… CONTINUE READING

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