Induction of neuronal differentiation by a peptide corresponding to the homophilic binding site of the second Ig module of the neural cell adhesion molecule.

@article{Soroka2002InductionON,
  title={Induction of neuronal differentiation by a peptide corresponding to the homophilic binding site of the second Ig module of the neural cell adhesion molecule.},
  author={Vladislav Soroka and Darya V. Kiryushko and V. N. Novitskaya and Lars C B Ronn and Flemming M. Poulsen and Arne Holm and Elisabeth Bock and Vladimir Berezin},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 27},
  pages={24676-83}
}
NCAM plays a key role in neural development and plasticity-mediating cell adhesion and differentiation mainly through homophilic binding. Until recently, attempts to modulate neuronal differentiation and plasticity through NCAM have been impeded by the absence of small synthetic agonists mimicking homophilic interactions of NCAM. We show here that a peptide, P2, corresponding to a 12-amino acid sequence localized in the FG loop of the second Ig module of NCAM, binds to the first Ig module… CONTINUE READING

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