Induction of neurogenesis in the neocortex of adult mice

  title={Induction of neurogenesis in the neocortex of adult mice},
  author={Sanjay S. P. Magavi and Blair R. Leavitt and Jeffrey D Macklis},
Neurogenesis normally only occurs in limited areas of the adult mammalian brain—the hippocampus, olfactory bulb and epithelium, and at low levels in some regions of macaque cortex. Here we show that endogenous neural precursors can be induced in situ to differentiate into mature neurons, in regions of adult mammalian neocortex that do not normally undergo any neurogenesis. This differentiation occurs in a layer- and region-specific manner, and the neurons can re-form appropriate corticothalamic… CONTINUE READING
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