Induction of natural killer activity by xanthenone analogues of flavone acetic acid: relation with antitumour activity.

@article{Ching1991InductionON,
  title={Induction of natural killer activity by xanthenone analogues of flavone acetic acid: relation with antitumour activity.},
  author={L. M. Ching and Wayne R. Joseph and Li Zhuang and Graham J. Atwell and Gordon William Rewcastle and William A. Denny and B. C. Baguley},
  journal={European journal of cancer},
  year={1991},
  volume={27 1},
  pages={79-83}
}
Flavone-8-acetic acid (FAA) induces haemorrhagic necrosis and tumour regression in experimental tumours and induces natural killer (NK) activity. Xanthenone-4-acetic acid (XAA) forms the basis of a series of analogues of FAA which vary in antitumour potency. FAA, XAA and 15 XAA derivatives were tested for their ability to induce either NK activity in mouse spleens or haemorrhagic necrosis in mouse colon 38 tumours. Some derivatives were active in both assays (one at a dose 8-fold lower than… CONTINUE READING

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