Induction of multiple heat shock proteins and neuroprotection in a primary culture model of familial amyotrophic lateral sclerosis

@article{Batulan2006InductionOM,
  title={Induction of multiple heat shock proteins and neuroprotection in a primary culture model of familial amyotrophic lateral sclerosis},
  author={Zarah Batulan and David C. M. Taylor and Rebecca J. Aarons and Sandra Minotti and Heather D. Durham},
  journal={Neurobiology of Disease},
  year={2006},
  volume={24},
  pages={213-225}
}
High threshold for stress-induced activation of the heat shock transcription factor, Hsf1, may contribute to vulnerability of motor neurons to disease and limit efficacy of agents promoting expression of neuroprotective heat shock proteins (Hsps) through this transcription factor. Plasmid encoding a constitutively active form of Hsf1, Hsf1act, and chemicals shown to activate Hsf1 in other cells were investigated in a primary culture model of familial amyotrophic lateral sclerosis. Hsf1act and… CONTINUE READING

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