Induction of multidrug resistance gene expression during cholestasis in rats and nonhuman primates.

@article{Schrenk1993InductionOM,
  title={Induction of multidrug resistance gene expression during cholestasis in rats and nonhuman primates.},
  author={Dieter Schrenk and Timothy W. Gant and K H Preisegger and Jeffrey A. Silverman and Pamela A. Marino and Snorri Thorgeirsson},
  journal={Hepatology},
  year={1993},
  volume={17 5},
  pages={854-60}
}
P-glycoprotein, an energy-dependent plasma membrane drug-efflux pump capable of reducing the intracellular concentration of a variety of hydrophobic xenobiotics, is encoded by mdr1, a member of the multidrug-resistant (mdr) gene family. The physiological function of this protein is unknown. Because of its location on the bile canalicular domain of the hepatocyte, we and others have hypothesized that P-glycoprotein may have a physiological role as a biliary transporter of xenobiotics and… CONTINUE READING

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