Induction of mucosal immunity with a replication-defective adenoviral recombinant.

@article{Xiang1999InductionOM,
  title={Induction of mucosal immunity with a replication-defective adenoviral recombinant.},
  author={Zhiquan Xiang and Hildegund C. J. Ertl},
  journal={Vaccine},
  year={1999},
  volume={17 15-16},
  pages={
          2003-8
        }
}
A replication-defective adenoviral recombinant expressing the rabies virus glycoprotein was tested for induction of transgene specific central and mucosal antibodies upon systemic inoculation or upon application to the mucosa of the airways, the rectum or the female genital tract. Mice developed serum and mucosal antibody titers to rabies virus upon subcutaneous or intranasal immunization with the latter route favoring induction of genital and intestinal secretion of antibodies of the IgA… CONTINUE READING