Induction of motor neuron sprouting in vivo by ciliary neurotrophic factor and basic fibroblast growth factor.

@article{Gurney1992InductionOM,
  title={Induction of motor neuron sprouting in vivo by ciliary neurotrophic factor and basic fibroblast growth factor.},
  author={Mark E Gurney and Hiroshi Yamamoto and Yong Wook Kwon},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1992},
  volume={12 8},
  pages={3241-7}
}
Ciliary neurotrophic factor (CNTF) and basic fibroblast growth factor (bFGF) were tested for effects on sprouting by motor neurons innervating the adult mouse gluteus muscle. Factors were delivered by subcutaneous injection directly over the surface of the superior gluteus muscle once daily for 7 d and then end plates and axons were visualized by combined silver and cholinesterase staining. CNTF (500 ng daily) induced sprouting both from end plates and from the subset of nodes of Ranvier that… CONTINUE READING

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