Induction of morphological changes in model lipid membranes and the mechanism of membrane disruption by a large scorpion-derived pore-forming peptide.

@article{Nomura2005InductionOM,
  title={Induction of morphological changes in model lipid membranes and the mechanism of membrane disruption by a large scorpion-derived pore-forming peptide.},
  author={Kaoru Nomura and Gilles Ferrat and Terumi Nakajima and Hervé Darbon and Takashi Iwashita and Gerardo Corzo},
  journal={Biophysical journal},
  year={2005},
  volume={89 6},
  pages={
          4067-80
        }
}
The membrane disruption mechanism of pandinin 1 (pin1), an antimicrobial peptide isolated from the venom of the African scorpion, was studied using 31P, 13C, 1H solid-state and multidimensional solution-state NMR spectroscopy. A high-resolution NMR solution structure of pin1 showed that the two distinct alpha-helical regions move around the central hinge region, which contains Pro19. 31P NMR spectra of lipid membrane in the presence of pin1, at various temperatures, showed that pin1 induces… 
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