Induction of monocyte chemoattractant protein-1 in HIV-1 Tat-stimulated astrocytes and elevation in AIDS dementia.

@article{Conant1998InductionOM,
  title={Induction of monocyte chemoattractant protein-1 in HIV-1 Tat-stimulated astrocytes and elevation in AIDS dementia.},
  author={Katherine Conant and Alfredo Garzino-Demo and Avindra Nath and Justin C. Mcarthur and William Halliday and Christopher Power and Robert C. Gallo and Eugene O. Major},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 6},
  pages={3117-21}
}
Activated monocytes release a number of substances, including inflammatory cytokines and eicosanoids, that are highly toxic to cells of the central nervous system. Because monocytic infiltration of the central nervous system closely correlates with HIV-1-associated dementia, it has been suggested that monocyte-derived toxins mediate nervous system damage. In the present study, we show that the HIV-1 transactivator protein Tat significantly increases astrocytic expression and release of monocyte… CONTINUE READING
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  • H. J. Gong, L. G. Ratkay, J. D. Waterfield, Clark-Lewis, I. J. Exp. Med. 186, 131–137. Medical Sciences
  • Proc. Natl. Acad. Sci. USA 95
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