Induction of monocyte chemoattractant protein-1 (MCP-1) and its receptor CCR2 in primary sensory neurons contributes to paclitaxel-induced peripheral neuropathy.

@article{Zhang2013InductionOM,
  title={Induction of monocyte chemoattractant protein-1 (MCP-1) and its receptor CCR2 in primary sensory neurons contributes to paclitaxel-induced peripheral neuropathy.},
  author={Haijun Zhang and Jessica A. Boyette-Davis and Alyssa K. Kosturakis and Y. M. Li and Sook-Young Yoon and Edgar T Walters and Patrick M Dougherty},
  journal={The journal of pain : official journal of the American Pain Society},
  year={2013},
  volume={14 10},
  pages={
          1031-44
        }
}
UNLABELLED The use of paclitaxel (Taxol), a microtubule stabilizer, for cancer treatment is often limited by its associated peripheral neuropathy (chemotherapy-induced peripheral neuropathy [CIPN]), which predominantly results in sensory dysfunction, including chronic pain. Here we show that paclitaxel CIPN was associated with induction of chemokine monocyte chemoattractant protein-1 (MCP-1) and its cognate receptor CCR2 in primary sensory neurons of dorsal root ganglia. Immunostaining revealed… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 45 CITATIONS

DRG Voltage-Gated Sodium Channel 1.7 Is Upregulated in Paclitaxel-Induced Neuropathy in Rats and in Humans with Neuropathic Pain.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2017
VIEW 4 EXCERPTS
CITES METHODS, BACKGROUND & RESULTS
HIGHLY INFLUENCED

Chemotherapy-induced peripheral neuropathy.

  • Progress in molecular biology and translational science
  • 2015
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED