Induction of mitosis-related genes during dopamine-triggered apoptosis in sympathetic neurons.

@article{Shirvan1997InductionOM,
  title={Induction of mitosis-related genes during dopamine-triggered apoptosis in sympathetic neurons.},
  author={Anat Shirvan and Ilan Ziv and Ari Barzilai and R Djaldeti and R Zilkh-Falb and T Michlin and Eldad Melamed},
  journal={Journal of neural transmission. Supplementum},
  year={1997},
  volume={50},
  pages={67-78}
}
It was suggested that neuronal degeneration in Parkinson's Disease (PD) is linked to dopamine (DA) toxicity. Dopamine has been shown to induce programmed cell death in both neuronal and non-neuronal cell types. We examined the molecular changes associated with dopamine-triggered apoptosis in sympathetic neurons using the differential display approach, and isolated 14 different DA responsive genes whose expression is altered during the early stages of the apoptotic process. Nine of these genes… CONTINUE READING