Induction of mitochondrial biogenesis is a maladaptive mechanism in mitochondrial cardiomyopathies.

  title={Induction of mitochondrial biogenesis is a maladaptive mechanism in mitochondrial cardiomyopathies.},
  author={Mariangela Sebastiani and Carla Giordano and Chiara Nediani and Claudia Travaglini and Elisabetta Borchi and Massimo Zani and Mariano Feccia and Massimiliano Mancini and Vincenzo Petrozza and Andrea Cossarizza and Pietro Gallo and Robert W Taylor and Giulia d'Amati},
  journal={Journal of the American College of Cardiology},
  volume={50 14},
OBJECTIVES The purpose of this study was to clarify the molecular mechanisms linking human mitochondrial deoxyribonucleic acid (mtDNA) dysfunction to cardiac remodeling. BACKGROUND Defects of the mitochondrial genome cause a heterogeneous group of clinical disorders, including mitochondrial cardiomyopathies (MIC). The molecular events linking mtDNA defects to cardiac remodeling are unknown. Energy derangements and increase of mitochondrial-derived reactive oxygen species (ROS) could both play… CONTINUE READING
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