Induction of midbrain dopaminergic neurons by Sonic hedgehog

  title={Induction of midbrain dopaminergic neurons by Sonic hedgehog},
  author={Mary Hynes and Jeffery A. Porter and Chin Lee Chiang and David T. Chang and Marc Tessier-Lavigne and Philip A Beachy and Arnon Rosenthal},
Midbrain dopaminergic neurons, whose loss in adults results in Parkinson's disease, can be specified during embryonic development by a contact-dependent signal from floor plate cells. Here we show that the amino-terminal product of Sonic hedgehog autoproteolysis (SHH-N), an inductive signal expressed by floor plate cells, can induce dopaminergic neurons in vitro. We show further that manipulations to increase the activity of cyclic AMP-dependent protein kinase A, which is known to antagonize… CONTINUE READING
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CAMP - dependent protein krnase and hedgehog act antagonistically in regulating decapentaplegic transduction in Drosophila imaginal discs

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Cell • 1995
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