Induction of microsatellite instability by oxidative DNA damage.

  title={Induction of microsatellite instability by oxidative DNA damage.},
  author={Andrew Jackson and Ren-wu Chen and L. A. Loeb},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={95 21},
Instability of repetitive sequences, both in intronic sequences and within coding regions, has been demonstrated to be a hallmark of genomic instability in human cancer. Understanding how these mutational events arise may provide an opportunity for prevention or early intervention in cancer development. To study the source of this instability, we have identified a region of the beta-lactamase gene that is tolerant to the insertion of fragments of exogenous DNA as large as 1,614 bp with minimal… CONTINUE READING


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