Induction of micronuclei in mouse bone marrow after combined X‐rays‐cyclophosphamide and X‐rays‐mitomycin C treatments

@article{Dobrzyska1999InductionOM,
  title={Induction of micronuclei in mouse bone marrow after combined X‐rays‐cyclophosphamide and X‐rays‐mitomycin C treatments},
  author={Małgorzata Dobrzyńska and Antoni K. Gajewski},
  journal={Teratogenesis Carcinogenesis and Mutagenesis},
  year={1999},
  volume={19},
  pages={267-274}
}
: The induction of micronuclei in polychromatic erythrocytes of bone marrow of Pzh:SWISS mice after combined treatment with X-rays and cyclophosphamide (CP) or X-rays and mitomycin C (MMC) were investigated. Combinations of high (1.00 Gy + 100 mg/kg bw CP and 1. 00 Gy + 5.25 mg/kg bw MMC) and low (0.25 Gy + 25 mg/kg bw CP and 0. 25 Gy + 1.75 mg/kg bw MMC) doses were used. Both chemicals enhanced the mutagenic effects caused by irradiation. After combined treatment with high doses of X-rays + CP… Expand
Micronucleus formation induced by the combination of low doses of X-rays and antineoplastic drugs in bone marrow of male mice.
  • M. Dobrzyńska
  • Chemistry, Medicine
  • Teratogenesis, carcinogenesis, and mutagenesis
  • 2000
TLDR
The effects of combined exposures of nonmutagenic doses of X-rays and anticancer agents (cyclophosphamide, mitomycin C, and vinblastine) have been investigated on the induction of micronuclei in the bone marrow of laboratory mice. Expand
The effects in mice of combined treatments to X-rays and antineoplastic drugs in the Comet assay.
TLDR
Strong increases of DNA damage in bone marrow lymphocytes and in germ cells were observed by comparison with the results obtained for each agent acting alone, but effects were observed over a similar dose range. Expand
Assessment of DNA damage in multiple organs from mice exposed to X-rays or acrylamide or a combination of both using the comet assay.
TLDR
Combined exposure to X-rays and AA enhanced DNA damage after single exposure to each agent. Expand
In vivo Evaluation of the Genotoxic Effects of Clomiphene Citrate on Rat Reticulocytes: A Micronucleus Genotoxicity
TLDR
In rats, the micronucleus genotoxicity assay suggests a dose-dependent CC effect on genomic instability in bone marrow stem cells in vivo, and this effect is associated with genotoxic effects on reticulocytes in vivo. Expand
In vivo evaluation of the genotoxic effects of gonadotropins on rat reticulocytes.
TLDR
In rats, the micronucleus genotoxicity assay suggests a dose-dependent gonadotropin effect on genomic instability in bone marrow stem cells in vivo, which is similar to that seen in women given ovulation-inducing drugs. Expand

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The induction of dominant lethal effects and sperm abnormalities in Pzh:Swiss male mice after treatments with X-rays and mitomycin C (MMC) was investigated and MMC increased the frequency of abnormal spermatozoa after exposure alone and in combination withX-rays. Expand
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