Induction of micronuclei in bone marrow of mice exposed to 1, 2 or 3 daily doses of urethane.

@article{Holmstrom1990InductionOM,
  title={Induction of micronuclei in bone marrow of mice exposed to 1, 2 or 3 daily doses of urethane.},
  author={M. Holmstrom},
  journal={Mutation research},
  year={1990},
  volume={234 3-4},
  pages={
          147-54
        }
}
  • M. Holmstrom
  • Published 1 June 1990
  • Biology, Medicine, Chemistry
  • Mutation research
Clastogenic activity of urethane in mice.
Bone marrow micronucleus assay: A review of the mouse stocks used and their published mean spontaneous micronucleus frequencies
TLDR
This analysis bears out the recommendation of the first Gene‐Tox Report on the micronucleus assay that the historical negative control frequency for a mouse stock should fall between 1 and 3 mnPCE/1,000 and suggests that the recommended range for historical mean frequency should be extended slightly.
Mutagenicity of ethyl carbamate to lacZ- transgenic mice.
TLDR
The mutagenicity of the rodent carcinogen ethyl carbamate (EC, urethane) has been assessed using the lacZ- transgenic mouse mutation assay (Muta Mouse) and statistically significant increases in mutation frequency (MF) in the lung and liver of the mice were observed.
In vivo rodent erythrocyte micronucleus assay.
Rat Pig-a mutation assay responds to the genotoxic carcinogen ethyl carbamate but not the non-genotoxic carcinogen methyl carbamate.
TLDR
The hypothesis that genotoxicity contributes to the carcinogenicity of EC but not of MC is supported, and the value of the Pig-a assay for discriminating between genotoxic and non-genotoxic modes of action is illustrated.
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References

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TLDR
A single dose of urethane produced a rise in the mitotic index, due essentially to a large increase in the metaphase index in the bone marrow of normal mice, which was found approximately at the same level as in the controls.
Distribution of urethane and its binding to DNA, RNA, and protein in SENCAR and BALB/c mice following oral and dermal administration.
TLDR
Differences in the distribution and binding of urethane probably do not account for the discrepancies in tumor sensitivity, and these differences were not observed at later time periods after oral administration.
Micronucleus formation by benzene, cyclophosphamide, benzo(a)pyrene, and benzidine in male, female, pregnant female, and fetal mice.
TLDR
Several factors must be interacting in different ways for different chemicals to influence their clastogenicity, and no single metabolite of benzene in the urine was consistently correlated with micronucleus formation in the bone marrow.
The kinetics of urethane elimination in the mouse.
An analysis of the changing urethan response of the developing mouse embryo in relation to mortality, malformation, and neoplasm.
TLDR
A quantitative analysis of the changing urethan response of the developing mouse embryo in relation to mortality, growth inhibition, malformation, and neoplasm was investigated, utilizing the fast action and unrestricted placental penetration of Urethan.
Inhibition of the localization of urethane in mouse tissues by ethanol.
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  • Medicine, Biology
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 1987
Some aspects of the metabolism of urethane and N-hydroxyurethane in rodents.
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  • Biology, Chemistry
    The Biochemical journal
  • 1968
TLDR
The rate of catabolism of N-hydroxyurethane by C57/DBA mice was faster in 8-day-old than in 1- day-old animals of the same sex, and faster in females than in males of thesame age.
The micronucleus test. Methodological aspects.
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