Induction of micronuclei in bone marrow and sperm head abnormalities after combined exposure of mice to low doses of X-rays and acrylamide.

@article{Dobrzyska2000InductionOM,
  title={Induction of micronuclei in bone marrow and sperm head abnormalities after combined exposure of mice to low doses of X-rays and acrylamide.},
  author={Małgorzata Dobrzyńska and Antoni K. Gajewski},
  journal={Teratogenesis, carcinogenesis, and mutagenesis},
  year={2000},
  volume={20 3},
  pages={
          133-40
        }
}
People come into contact with chemical and physical agents which are present in the environment and in workplaces. We investigated the effects of combined exposures to low doses of X-rays (0.05-0.25 Gy) and acrylamide (AA; 75 mg/kg bw) in the somatic and germ cells of outbred male mice by using a bone-marrow micronucleus test and a sperm morphology test. Combined treatment of germ cells to 0.25 Gy of X-rays + 75 mg/kg bw of acrylamide enhanced the effect induced by each agent given alone. The… Expand
[Frequency of micronuclei in erythrocytes of mice subchronic exposed to ionising radiation and nonylphenol].
  • M. Dobrzyńska
  • Biology, Medicine
  • Roczniki Panstwowego Zakladu Higieny
  • 2008
TLDR
Combined X-rays-NP exposure of peripheral blood reticulocytes and bone marrow polychromatic erythrocytes caused enhanced frequency of micronuclei compared to the effect of each agent alone, and after combined exposure to both agents in higher doses, nonylphenol may protected DNA of reticULocytes against damage induced by X-ray. Expand
[Frequency of micronuclei in reticulocytes of male mice exposed to bisphenol A and to a combination of x-rays and bisphenol A].
TLDR
Ionising radiation is probably the agent which decided about damage and/or unequal distribution of chromosomes following combined exposure together with bisphenol A, which seems to be weak mutagen. Expand
Assessment of DNA damage in multiple organs from mice exposed to X-rays or acrylamide or a combination of both using the comet assay.
TLDR
Combined exposure to X-rays and AA enhanced DNA damage after single exposure to each agent. Expand
[The influence of bisphenol A and of combined exposure to X-rays and bisphenol A to somatic cells of the bone marrow and liver of mice].
TLDR
It was showed that BPA can induce, measured by Comet assay, DNA damage in limphocytes of the bone marrow and the induction ofDNA damage in somatic cells of the liver, and that after combined exposure to both agents a greater migration of DNA in cells of both organs than after the exposure to bisphenol A alone was observed. Expand
Genotoxicity and reproductive toxicity of bisphenol A and X-ray/bisphenol A combination in male mice
TLDR
Levels of DNA damage in somatic and germ cells after combined exposure to lower, as well as higher, doses were significantly reduced, compared to the effects of BPA alone. Expand
Combined action of X-rays and nonylphenol on mouse sperm
TLDR
Results of combined exposure to low doses of both agents suggest that 0.05 Gy of X-rays stimulate the DNA damagecontrol system and in consequence repair of DNA caused by X-ray and NP may be correlated with increased antioxidant capacity. Expand
Increased micronucleus frequency in rat bone marrow after acrylamide treatment.
  • Y. Yener, M. Dikmenli
  • Chemistry, Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2009
TLDR
It was displayed that AA increased the formation of micronuclei in polychromatic erythrocytes (PCEs) of rat bone marrow and this increase might have resulted from administrating the high dose level of AA to rats by gavage instead of by i.p.w. injection. Expand
Effects of acrylamide on sperm parameters, chromatin quality, and the level of blood testosterone in mice
TLDR
According to the results, AA can affect sperm parameters as well as sperm chromatin condensation and DNA integrity in mice and these abnormalities may be related to the reduction in blood testosterone. Expand
Chemoprevention of Barley and Sage against acrylamide-Induced genotoxic, biochemical and histopathological alterations in rats
TLDR
Cotreatment with barley and/or Sage and ACR resulted in a significant improvement in all the parameters tested, and it could be concluded that these plants contain antioxidant compounds and may be useful when add as food additive to the food cooked on a higher temperature. Expand
Abnormal sperm morphology in mouse germ cells after short-term exposures to acetamiprid, propineb, and their mixture
  • P. G. Rasgele
  • Chemistry, Medicine
  • Arhiv za higijenu rada i toksikologiju
  • 2014
TLDR
Results suggest that Acm was non-genotoxic for mouse germ cells, while Pro may have been a germ cell mutagen due to the observed increase in the frequency of sperm abnormalities, and to gain better insight into the mutagenicity and DNA damaging potential of both of these pesticides. Expand
...
1
2
3
...

References

SHOWING 1-10 OF 42 REFERENCES
Mouse dominant lethal and sperm abnormality studies with combined exposure to X-rays and mitomycin C.
TLDR
The induction of dominant lethal effects and sperm abnormalities in Pzh:Swiss male mice after treatments with X-rays and mitomycin C (MMC) was investigated and MMC increased the frequency of abnormal spermatozoa after exposure alone and in combination withX-rays. Expand
Induction of dominant lethal mutations by combined X-ray-acrylamide treatment in male mice.
The induction of mutations following combined treatment with acrylamide (AA) plus X-rays has been determined using the dominant lethal mutations test in Pzh:SFISS male mice. Combinations of aExpand
Evaluation of spermatogenic response of mice to the induction of mutations by combined treatment with X rays and antineoplastic drugs
TLDR
Enhanced risk could be shown not only after high but also after low combined exposure to X-ray plus cyclophosphamide and X-rays plus mitomycin C, and with low doses this enhanced risk was observed in spermatids for X- Ray exposure and in differentiating s permatogonia to early sperMatocytes for X/ray exposure. Expand
Increased frequencies of micronuclei in early spermatids of rats following exposure of young primary spermatocytes to acrylamide.
TLDR
Comparative studies indicated that the original 'suspension method' can be simplified by omitting enzyme treatments for the release of germ cells from the seminiferous tubules in spermatocytes exposed to single or fractionated doses of acrylamide. Expand
Radiation-induced micronucleus formation in mouse bone marrow after low dose exposures.
TLDR
It was observed that the frequency of micronucleated polychromatic erythrocytes (MPCE) increased with the increase in exposure dose at all the post-irradiation time periods studied and the dose-response relationship was linear-quadratic for both MPCE and MNCE. Expand
Weak genotoxicity of acrylamide on premeiotic and somatic cells of the mouse.
TLDR
The application of the MN test in peripheral blood reticulocytes of the same animals used for the spermatid MN assay indicated that the cytogenetic effects induced by AA in the somatic and the germ cell lines are comparable in magnitude. Expand
Potentiation by caffeine of the frequencies of micronuclei induced by mitomycin C and cyclophosphamide in young mice.
TLDR
The pregnancy had no effect on MMC- or CP-induced clastogenicity although a tendency to a decreased sensitivity to the damaging activity of MMC seemed to be detected in pregnant C57Bl mice compared to virgin female animals. Expand
Clastogenic effects of acrylamide in mouse bone marrow cells.
TLDR
The present results demonstrate that acrylamide is no exception among clastogens, which breaks chromosomes not only in mammalian germ cells but also in somatic cells. Expand
Effects of X-irradiation on the kinetics of abnormal sperm production and sperm loss in the mouse.
  • G. C. Pogany
  • Biology, Medicine
  • Journal of reproduction and fertility
  • 1987
TLDR
The synchrony that existed among the various organs in terms of both sperm loss and the generation of abnormal spermatozoa may be the result of a rapid dispersion of gametes from the testis and not due to local responses as would be expected if sperm flow were affected by the irradiation. Expand
Dose response at low doses of X-irradiation and MMS on the induction of micronuclei in mouse erythroblasts.
TLDR
The test of induced micronuclei in erythrocytes of mammalian bone marrow constitutes a suitable method for the screening of induced chromosomal lesions at very low dosages of chemicals or irradiations, and suggests that X-irradiation does not interfere with the repair process operating with MMS. Expand
...
1
2
3
4
5
...