Induction of metastasis, cancer stem cell phenotype, and oncogenic metabolism in cancer cells by ionizing radiation

@inproceedings{Lee2016InductionOM,
  title={Induction of metastasis, cancer stem cell phenotype, and oncogenic metabolism in cancer cells by ionizing radiation},
  author={Su Yeon Lee and Eui Kyong Jeong and Min Kyung Ju and Hyun Min Jeon and Min Young Kim and Cho Hee Kim and Hye Gyeong Park and Song Iy Han and Ho Sung Kang},
  booktitle={Molecular Cancer},
  year={2016}
}
Radiation therapy is one of the major tools of cancer treatment, and is widely used for a variety of malignant tumours. Radiotherapy causes DNA damage directly by ionization or indirectly via the generation of reactive oxygen species (ROS), thereby destroying cancer cells. However, ionizing radiation (IR) paradoxically promotes metastasis and invasion of cancer cells by inducing the epithelial-mesenchymal transition (EMT). Metastasis is a major obstacle to successful cancer therapy, and is… CONTINUE READING
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