Induction of mesothelioma in p53+/- mouse by intraperitoneal application of multi-wall carbon nanotube.

@article{Takagi2008InductionOM,
  title={Induction of mesothelioma in p53+/- mouse by intraperitoneal application of multi-wall carbon nanotube.},
  author={Atsuya Takagi and Akihiko Hirose and Tetsuji Nishimura and Nobutaka Fukumori and Akio Ogata and Norio Ohashi and Satoshi Kitajima and Jun Kanno},
  journal={The Journal of toxicological sciences},
  year={2008},
  volume={33 1},
  pages={105-16}
}
Nanomaterials of carbon origin tend to form various shapes of particles in micrometer dimensions. Among them, multi-wall carbon nanotubes (MWCNT) form fibrous or rod-shaped particles of length around 10 to 20 micrometers with an aspect ratio of more than three. Fibrous particles of this dimension including asbestos and some man-made fibers are reported to be carcinogenic, typically inducing mesothelioma. Here we report that MWCNT induces mesothelioma along with a positive control, crocidolite… CONTINUE READING
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