Induction of mesenchymal stem cell chondrogenic differentiation and functional cartilage microtissue formation for in vivo cartilage regeneration by cartilage extracellular matrix-derived particles.

@article{Yin2016InductionOM,
  title={Induction of mesenchymal stem cell chondrogenic differentiation and functional cartilage microtissue formation for in vivo cartilage regeneration by cartilage extracellular matrix-derived particles.},
  author={Heyong Yin and Yu Wang and Zhen Sun and Xun Sun and Yichi Xu and Pan Li and Haoye Meng and Xiaoming Yu and Bo Xiao and Tian Fan and Yiguo Wang and Wenjing Xu and Aiyuan Wang and Quanyi Guo and Jiang Peng and Shibi Lu},
  journal={Acta biomaterialia},
  year={2016},
  volume={33},
  pages={96-109}
}
UNLABELLED We propose a method of preparing a novel cell carrier derived from natural cartilage extracellular matrix (ECM), designated cartilage ECM-derived particles (CEDPs). Through a series of processes involving pulverization, sieving, and decellularization, fresh cartilage was made into CEDPs with a median diameter of 263 ± 48 μm. Under microgravity culture conditions in a rotary cell culture system (RCCS), bone marrow stromal cells (BMSCs) can proliferate rapidly on the surface of CEDPs… CONTINUE READING
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