Induction of melanoma phenotypes in human skin by growth factors and ultraviolet B.

@article{Berking2004InductionOM,
  title={Induction of melanoma phenotypes in human skin by growth factors and ultraviolet B.},
  author={Carola Berking and Richelle C. Takemoto and Kapaettu Satyamoorthy and Takahashi Shirakawa and Malihe Eskandarpour and Johan Hansson and Patricia A. VanBelle and David E. Elder and Meenhard Herlyn},
  journal={Cancer research},
  year={2004},
  volume={64 3},
  pages={807-11}
}
Exposure to UV radiation likely plays a key role in melanoma development, whereas other etiologic agents remain unknown. Here we show that in normal human skin an increased expression of a combination of three growth factors, basic fibroblast growth factor, stem cell factor, and endothelin-3, along with exposure to UVB can transform normal melanocytes into a melanoma phenotype within 4 weeks. Invasion of melanoma lesions was found in skin from newborn donors, whereas melanomas in adult skin… CONTINUE READING

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