Induction of megakaryocytopoiesis and thrombocytopoiesis by JTZ-132, a novel small molecule with thrombopoietin mimetic activities.

@article{Inagaki2004InductionOM,
  title={Induction of megakaryocytopoiesis and thrombocytopoiesis by JTZ-132, a novel small molecule with thrombopoietin mimetic activities.},
  author={Koji Inagaki and Tomohiro Oda and Yuichi Naka and Hisashi Shinkai and Norio Komatsu and Hiroyuki Iwamura},
  journal={Blood},
  year={2004},
  volume={104 1},
  pages={58-64}
}
We report in this paper that a novel small molecule, JTZ-132, induced growth and differentiation of megakaryocytic progenitor cells and improved thrombocytopenia in myelosuppressed mice. JTZ-132 stimulated proliferation of UT-7/TPO cells, a cell line highly sensitive to thrombopoietin (TPO), and exhibited full efficacy comparable to TPO with an approximate EC(50) (median effective concentration) value of 0.43 microM, whereas little proliferation was observed in a TPO-insensitive cell line, UT-7… CONTINUE READING

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